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Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA). [7] It is used in the treatment of various conditions, most notably obsessive–compulsive disorder but also many other disorders, including hyperacusis, panic disorder, major depressive disorder, trichotillomania, [8] body dysmorphic disorder [9] [10] [11] and chronic pain. [7]
The following other wikis use this file: Usage on ar.wikipedia.org كلوميبرامين; Usage on cs.wikipedia.org Klomipramin; Usage on cy.wikipedia.org
Norclomipramine, also known as N-desmethylclomipramine and chlordesipramine, is the major active metabolite of the tricyclic antidepressant (TCA) clomipramine (Anafranil). [ 1 ] References
This is an accepted version of this page This is the latest accepted revision, reviewed on 7 January 2025. Book containing line art, to which the user is intended to add color For other uses, see Coloring Book (disambiguation). Filled-in child's coloring book, Garfield Goose (1953) A coloring book is a type of book containing line art to which people are intended to add color using crayons ...
Conversely, in spite of variably acting as serotonin 5-HT 2A receptor antagonists, tricyclic antidepressants (TCAs), including desipramine, imipramine, and clomipramine, have paradoxically been reported to potentiate the effects of serotonergic psychedelics rather than diminish them. [6]
In the late 1950s, imipramine was the first TCA to be developed (by Ciba). At the first international congress of neuropharmacology in Rome, September 1958 Dr Freyhan from the University of Pennsylvania discussed as one of the first clinicians the effects of imipramine in a group of 46 patients, most of them diagnosed as "depressive psychosis ...
Desipramine, sold under the brand name Norpramin among others, is a tricyclic antidepressant (TCA) used in the treatment of depression. [8] It acts as a relatively selective norepinephrine reuptake inhibitor, though it does also have other activities such as weak serotonin reuptake inhibitory, α 1-blocking, antihistamine, and anticholinergic effects.
The side effects of trimipramine have been said to be similar to those of other tertiary amine TCAs, with a preponderance of anticholinergic and sedative effects. [9] However, trimipramine has also been said to be associated with a different side effect profile compared to other TCAs and in general with fewer side effects, chiefly due to its lack of norepinephrine reuptake inhibition and ...