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The Armitage–Doll model is a statistical model of carcinogenesis, proposed in 1954 by Peter Armitage and Richard Doll, in which a series of discrete mutations result in cancer. [1] The original paper has recently been reprinted with a set of commentary articles.
Cancer slope factors (CSF) are used to estimate the risk of cancer associated with exposure to a carcinogenic or potentially carcinogenic substance. A slope factor is an upper bound, approximating a 95% confidence limit , on the increased cancer risk from a lifetime exposure to an agent by ingestion or inhalation .
The first clinical prediction model reporting guidelines were published in 2015 (Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD)), and have since been updated. [10] Predictive modelling has been used to estimate surgery duration.
Ethinylestradiol (EE) is an estrogen medication which is used widely in birth control pills in combination with progestins. [7] [8] In the past, EE was widely used for various indications such as the treatment of menopausal symptoms, gynecological disorders, and certain hormone-sensitive cancers.
The original model uses an iterative three-stage modeling approach: Model identification and model selection: making sure that the variables are stationary, identifying seasonality in the dependent series (seasonally differencing it if necessary), and using plots of the autocorrelation (ACF) and partial autocorrelation (PACF) functions of the dependent time series to decide which (if any ...
This value is very useful in determining the therapeutic benefit or risk to patients in experimental groups, in comparison to patients in placebo or traditionally treated control groups. [citation needed] Three statistical terms rely on EER for their calculation: absolute risk reduction, relative risk reduction and number needed to treat.
Specifically, obesity, type II diabetes, and insulin resistance are risk factors for Type I endometrial cancer. [21] Obesity increases the risk for endometrial cancer by 300–400%. [22] Estrogen replacement therapy during menopause when not balanced (or "opposed") with progestin is another risk factor.
MMTV-PyMT is the model of breast cancer metastasis, in which MMTV-LTR is used to drive the expression of mammary gland specific polyomavirus middle T-antigen, leading to a rapid development of highly metastatic tumors. [45] MMTV-PyMT is the most commonly used model for the study of mammary tumor progression and metastasis.