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The free radical theory of aging states that organisms age because cells accumulate free radical damage over time. [ 1 ] A free radical is any atom or molecule that has a single unpaired electron in an outer shell. [ 2 ] While a few free radicals such as melanin are not chemically reactive, most biologically relevant free radicals are highly ...
Calorie restriction (also known as caloric restriction or energy restriction) is a dietary regimen that reduces the energy intake from foods and beverages without incurring malnutrition. [ 1 ][ 2 ] The possible effect of calorie restriction on body weight management, longevity, and aging-associated diseases has been an active area of research.
All it takes, he believes, is new technology—yet to be created—that can eliminate aging at the cellular level, repair DNA, and reprogram cells for a drastically different aging process.
These findings were independent, in that more sugar meant more accelerated biological age, even if a woman's overall diet was healthier, but sticking to a healthier overall diet was associated ...
Cellular senescence is a phenomenon characterized by the cessation of cell division. [ 1 ][ 2 ][ 3 ] In their experiments during the early 1960s, Leonard Hayflick and Paul Moorhead found that normal human fetal fibroblasts in culture reach a maximum of approximately 50 cell population doublings before becoming senescent. [ 4 ][ 5 ][ 6 ] This ...
PARIS — With the aim of reversing cellular aging, Parfums Christian Dior has entered into a research collaboration with Vadim N. Gladyshev, a professor of medicine at Brigham and Women’s ...
The hallmarks of aging are the types of biochemical changes that occur in all organisms that experience biological aging and lead to a progressive loss of physiological integrity, impaired function and, eventually, death. They were first listed in a landmark paper in 2013 [1] to conceptualize the essence of biological aging and its underlying ...
Hypothesis that aging is caused by accumulated DNA damage. The DNA damage theory of agingproposes that agingis a consequence of unrepaired accumulation of naturally occurring DNA damage. Damage in this context is a DNA alteration that has an abnormal structure. Although both mitochondrialand nuclearDNA damage can contribute to aging, nuclear ...