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A cell during anaphase. Microtubules are visible in green. Stages of late M phase in a vertebrate cell. Anaphase (from Ancient Greek ἀνα-() 'back, backward' and φάσις (phásis) 'appearance') is the stage of mitosis after the process of metaphase, when replicated chromosomes are split and the newly-copied chromosomes (daughter chromatids) are moved to opposite poles of the cell.
Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin (Apc2) and RING (Apc11) subunit much like SCF. Other parts of the APC/C have unknown functions but are ...
Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene. [5] [6]A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome.
Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene. [5] [6] The anaphase-promoting complex (APC) consists of at least 8 protein subunits, including APC5, CDC27 (APC3; MIM 116946), CDC16 (APC6; MIM 603461), and CDC23 (APC8; MIM 603462).[supplied by OMIM] [6]
Anaphase lag is a consequence of an event during cell division where sister chromatids do not properly separate from each other because of improper spindle formation. [1] The chromosome or chromatid does not properly migrate during anaphase and the daughter cells will lose some genetic information. It is one of many causes of aneuploidy.
View/Edit Human. View/Edit Mouse. Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene. [5] Multiple transcript variants encoding different isoforms have been found for this gene.
Microtubule polymerization is nucleated at the microtubule organizing center. An aster is a cellular structure shaped like a star, consisting of a centrosome and its associated microtubules during the early stages of mitosis in an animal cell. [ 1 ]: 221 Asters do not form during mitosis in plants. Astral rays, composed of microtubules, radiate ...
The Russian Wikipedia (Russian: Русская Википедия, romanized:Russkaya Vikipediya) is the Russian-language edition of Wikipedia. As of October 2024, it has 2,003,653 articles. It was started on 11 May 2001. [ 1 ] In October 2015, it became the sixth-largest Wikipedia by the number of articles.