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Cannabinoid hyperemesis syndrome. Cannabinoid hyperemesis syndrome (CHS) is recurrent nausea, vomiting, and cramping abdominal pain that can occur due to prolonged, high-dose cannabis use. [ 4 ][ 5 ] Complications are related to persistent vomiting and dehydration which may lead to kidney failure and electrolyte problems. [ 2 ]
Cannabis drug testing describes various drug test methodologies for the use of cannabis in medicine, sport, and law. Cannabis use is highly detectable and can be detected by urinalysis, hair analysis, as well as saliva tests for days or weeks. Unlike alcohol, for which impairment can be reasonably measured using a breathalyser (and confirmed ...
Duquenois–Levine reagent. The Duquenois reagent is used in the Rapid Modified Duquenois–Levine test (also known as the simple Rapid Duquenois Test), which is an established screening test for the presence of cannabis. The test was initially developed in the 1930s by the French medical biochemist Pierre Duquénois (1904–1986) and was ...
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However, due to first-pass metabolism in the liver and the high lipid solubility of THC, only about 5 to 20% reaches circulation. [3] [21] Following oral administration, concentrations of THC and its major active metabolite 11-hydroxy-THC (11-OH-THC) peak after 0.5 to 4 hours, with median time to peak of 1.0 to 2.5 hours at different doses.
A dried cannabis flower. The short-term effects of cannabis are caused by many chemical compounds in the cannabis plant, including 113 [clarification needed] different cannabinoids, such as tetrahydrocannabinol (THC), and 120 terpenes, [1] which allow its drug to have various psychological and physiological effects on the human body.
Over time, the marijuana gateway hypothesis has been studied more and more. In one published study, the use of marijuana was shown not a reliable gateway cause of illicit drug use. [67] However, social factors and environment influence drug use and abuse, making the gateway effects of cannabis different for those in differing social circumstances.
Cannabidiol (CBD) is a phytocannabinoid, one of 113 identified cannabinoids in cannabis plants, along with tetrahydrocannabinol (THC), and accounts for up to 40% of the plant's extract. [18] Medically, it is an anticonvulsant used to treat multiple forms of epilepsy. [4]