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In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. [3] A trough level is contrasted with a "peak level" (C max), which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It is ...
Peak-to-trough ratio in pharmacokinetics is the ratio of peak (C max) and trough (C min) levels of a drug over its dosing interval (τ) at steady state.. Peak-to-trough ratio (PTR), also known as peak-to-trough variation or peak-to-trough fluctuation, is a parameter in pharmacokinetics which is defined as the ratio of C max (peak) concentration and C min (trough) concentration over a dosing ...
Short term drug side effects are most likely to occur at or near the C max, whereas the therapeutic effect of drug with sustained duration of action usually occurs at concentrations slightly above the C min. [citation needed] The C max is often measured in an effort to show bioequivalence (BE) between a generic and innovator drug product. [4]
This definition is slightly different from C trough, the concentration immediately prior to administration of the next dose. [1] C min is the opposite of C max, the maximum concentration that the drug reaches. C min must be above certain thresholds, such as the minimum inhibitory concentration (MIC), to achieve a therapeutic effect. [2]
English Possible confusion aa, āā, ĀĀ ana of each AAA apply to affected area abdominal aortic aneurysm: a.c. ante cibum: before meals a.c.h.s., ac&hs ante cibum et hora somni: before meals and at bedtime a.d. auris dextra: right ear a single-storey a can be mistaken as an o which could read "o.d.", meaning right eye ad., add. adde addatur: add
Similarly, when the intravenous infusion is ended, the drug concentration decreases exponentially and reaches an undetectable level after 5–6 half-lives have passed. [ 5 ] [ 6 ] If the same drug is administered as a bolus (medicine) with a single injection, peak concentration is achieved almost immediately and then the concentration declines ...
Trough (geology), a long depression less steep than a trench; Trough (meteorology), an elongated region of low atmospheric pressure; Trough (physics), the lowest point on a wave; Trough level (medicine), the lowest concentration of a medicine is present in the body over time; Langmuir-Blodgett trough, a laboratory instrument
Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein.The intravenous route of administration is commonly used for rehydration or to provide nutrients for those who cannot, or will not—due to reduced mental states or otherwise—consume food or water by mouth.