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A major systematic review and network meta-analysis of medications for the treatment of insomnia published in 2022 found that trimipramine had an effect size (standardized mean difference (SMD)) against placebo for treatment of insomnia at 4 weeks of 0.55 (95% CI Tooltip confidence interval –0.11 to 1.21). [14]
Chamomile: It has been used over history for a variety of conditions, including sleeplessness and anxiety. [103] Medicago sativa: Alfalfa: The leaves are purported to lower cholesterol, and treat kidney and urinary tract ailments, although there is insufficient scientific evidence for its efficacy. [104] Melaleuca alternifolia: Tea tree oil
Chamomile may be used as a flavouring agent in foods and beverages, mouthwash, soaps, and cosmetics. [5] Chamomile tea is a herbal infusion made from dried flowers and hot water, and may improve sleep quality. [3] Two types of chamomile are used, namely German chamomile (Matricaria recutita) and Roman chamomile (Chamaemelum nobile). [3]
Matricaria chamomilla (synonym: Matricaria recutita), commonly known as chamomile (also spelled camomile), German chamomile, [2] Hungarian chamomile (kamilla), wild chamomile, blue chamomile, or scented mayweed, [3] [4] is an annual plant of the composite family Asteraceae.
Meprobamate—marketed as Miltown by Wallace Laboratories and Equanil by Wyeth, among others—is a carbamate derivative used as an anxiolytic drug. It was the best-selling minor tranquilizer for a time, but has largely been replaced by the benzodiazepines due to their wider therapeutic index (lower risk of toxicity at therapeutically prescribed doses) and lower incidence of serious side effects.
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