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Sepsivac is a drug developed by Cadila Pharmaceuticals to treat gram-negative sepsis. The active ingredient is heat-killed Mycobacterium w, a non-pathogenic strain of Mycobacterium . As an immunomodulatory , it modulates the immune system of the body and hence significantly reduces mortality rate in patients with gram negative sepsis.
Sepsis requires immediate treatment with intravenous fluids and antimicrobial medications. [1] [5] Ongoing care and stabilization often continues in an intensive care unit. [1] If an adequate trial of fluid replacement is not enough to maintain blood pressure, then the use of medications that raise blood pressure becomes necessary. [1]
Xigris was designed to fight sepsis, a condition that kills more than 200,000 Americans annually. It was the only approved drug for sepsis, and it costs $8,000 to treat a single patient. Lilly hoped it would be a blockbuster, with sales of at least a billion dollars a year. But after five years on the market, sales were only $200 million.
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Cefotaxime is an antibiotic used to treat several bacterial infections in humans, other animals, and plant tissue culture. [3] Specifically in humans it is used to treat joint infections, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, sepsis, gonorrhea, and cellulitis. [3]
Ceftazidime is used to treat lower respiratory tract, skin, urinary tract, blood-stream, joint, and abdominal infections, and meningitis. [10] Ceftazidime is the first-line treatment for the tropical infection, melioidosis, an important cause of sepsis in Asia and Australia. [11] [12] Labeled indications include the treatment of patients with:
"Patients can go from being well to very sick within hours." ... learning difficulties or limb amputations due to sepsis. "Early recognition and treatment are critical to preventing these outcomes ...
It is used to treat pelvic inflammatory disease, intra-abdominal infection, pneumonia, cellulitis, and sepsis. [4] It is given by injection into a vein. [5] Common adverse effects include headache, trouble sleeping, rash, nausea, constipation, and diarrhea. [4]