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A cold sore [a] is a type of herpes infection caused by the herpes simplex virus that affects primarily the lip. [1] Symptoms typically include a burning pain followed by small blisters or sores . [ 1 ]
In July 2000, docosanol was approved for medical use in the United States as an antiviral agent for reducing the duration of cold sores. [ 3 ] [ 4 ] [ 7 ] It is an over-the-counter medication (OTC). It is sold under the brand name Abreva among others.
Oral herpes involves the face or mouth. It may result in small blisters in groups, often called cold sores or fever blisters, or may just cause a sore throat. [2] [6] Genital herpes involves the genitalia. It may have minimal symptoms or form blisters that break open and result in small ulcers. [1] These typically heal over two to four weeks. [1]
The spread is facilitated when a sore is present but it can happen in its absence as well. The patients may know that the virus is present on the skin when they experience the so-called "prodromal symptoms". These include itching or tingling on the skin, right before the blisters or lesions appear. The virus may spread since the first symptoms ...
After treatment of genetically marked HSV with trimethylpsoralen, recombination between the marked viruses increases, suggesting that trimethylpsoralen damage stimulates recombination. [76] MR of HSV appears to partially depend on the host cell recombinational repair machinery since skin fibroblast cells defective in a component of this ...
The mouth may act as a reservoir of Candida that reinfects the sores at the corners of the mouth and prevents the sores from healing. [citation needed] A lesion caused by recurrence of a latent herpes simplex infection can occur in the corner of the mouth. This is herpes labialis (a cold sore), and is sometimes termed "angular herpes simplex". [2]
The instructions on the TCP bottle state that TCP can be used for sore throats, mouth ulcers, cuts, grazes, bites and stings, boils, spots and pimples. [6] It can also be used as a mouthwash when diluted, and can also be used as a general disinfectant. [citation needed]
Treatment [ edit ] Although it is a self-limited illness, oral or intravenous antiviral treatments, particularly acyclovir , have been used in the management of immunocompromised or severely infected patients.