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Drug reaction with eosinophilia and systemic symptoms; Toxic epidermal necrolysis [c] Ataxia [d] Clostridioides difficile colitis; Aseptic meningitis [e] Pseudomembranous colitis; Interstitial nephritis; Fulminant hepatic necrosis; Hypersensitivity of the respiratory tract; Sore throat; Pallor; Arthralgia
The effects of trimethoprim causes a backlog of dihydrofolate (DHF) and this backlog can work against the inhibitory effect the drug has on tetrahydrofolate biosynthesis. This is where the sulfamethoxazole comes in; its role is in depleting the excess DHF by preventing it from being synthesised in the first place.
Trimethoprim may cause sun sensitivity. [1] There is evidence of potential harm during pregnancy in some animals but not humans. [3] It works by blocking folate metabolism via dihydrofolate reductase in some bacteria, preventing creation of bacterial DNA and RNA and leading to bacterial cell death. [1] Trimethoprim was first used in 1962. [4]
Sulfamethoxazole (SMZ or SMX) is an antibiotic.It is used for bacterial infections such as urinary tract infections, bronchitis, and prostatitis and is effective against both gram negative and positive bacteria such as Escherichia coli and Listeria monocytogenes.
Lightheadedness is a common and typically unpleasant sensation of dizziness [1] or a feeling that one may faint. The sensation of lightheadedness can be short-lived, prolonged, or, rarely, recurring. In addition to dizziness, the individual may feel as though their head is weightless.
For example, after a 4.8 magnitude earthquake hit New Jersey in April, people in the affected areas reported symptoms including dizziness, vertigo, nausea and just generally feeling a bit off.
Growth indicated a bacterial meningitis, while no growth indicated another cause denoted "aseptic" meningitis. [1] The most common form of this is viral meningitis. [1] Recent medical advances allows rapid polymerase chain reaction (PCR) testing that analyzes the CSF for DNA or RNA. This can quickly determine if there are bacterial or viral ...
Dizziness is a common medical complaint, affecting 20–30% of persons. [4] Dizziness is broken down into four main subtypes: vertigo (~25–50%), disequilibrium (less than ~15%), presyncope (less than ~15%), and nonspecific dizziness (~10%). [5] Vertigo is the sensation of spinning or having one's surroundings spin about them. Many people find ...