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These growth factors modulate the differentiation of progenitor cells into osteoprogenitor cells, which are responsible for bone and cartilage formation. As a result of the demineralization process, DBM is more biologically active than undemineralized bone grafts; conversely the mechanical properties are significantly diminished. [citation needed]
The result is mineral formation not strongly controlled by the cellular processes of the animal host (i.e., remote mineralization); this may lead to unusual crystal morphologies. [ 10 ] Biologically influenced mineralization takes place when chemical conditions surrounding the site of mineral formation are influenced by abiotic processes (e.g ...
The cells of our bone that is involved in bone formation and bone breakdown is osteoblast and osteoclast respectively. Osteoclasts are cells of bones that promote bone demineralization or bone resorption. [3] In contrast, Osteoblast promotes calcium absorption by the bone therefore, promoting bone mineralization and formation of new bones. [2]
Bone tissue is a dynamic system with active metabolism. [24] Bone tissue remodelling or bone remodeling is a successive chain of old bone matrix removal and its replacement with a new one. [25] These processes make a child’s skeleton grow and extend, while childhood is characterized by bone tissue growth rather than its resorption.
Demineralization is the opposite process of mineralization; it is a process of reduction in the mineral content in tissue or an organism. Examples include bone demineralization or tooth demineralization. Demineralization can lead to serious diseases such as osteoporosis, rickets, or tooth decay. [1]
Mineralization may refer to: Biomineralization (mineralization in biology), when an inorganic substance precipitates in an organic matrix Mineralized tissues are tissues that have undergone mineralization, including bones, teeth, antlers, and marine shells Bone remodeling, involving demineralization and remineralization in bones
Osteomalacia is a disease characterized by the softening of the bones caused by impaired bone metabolism primarily due to inadequate levels of available phosphate, calcium, and vitamin D, or because of resorption of calcium. The impairment of bone metabolism causes inadequate bone mineralization.
Bone tissue is removed by osteoclasts, and then new bone tissue is formed by osteoblasts. Both processes utilize cytokine (TGF-β, IGF) signalling.In osteology, bone remodeling or bone metabolism is a lifelong process where mature bone tissue is removed from the skeleton (a process called bone resorption) and new bone tissue is formed (a process called ossification or new bone formation).