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Osteomalacia is a disease characterized by the softening of the bones caused by impaired bone metabolism primarily due to inadequate levels of available phosphate, calcium, and vitamin D, or because of resorption of calcium. The impairment of bone metabolism causes inadequate bone mineralization.
These growth factors modulate the differentiation of progenitor cells into osteoprogenitor cells, which are responsible for bone and cartilage formation. As a result of the demineralization process, DBM is more biologically active than undemineralized bone grafts; conversely the mechanical properties are significantly diminished. [citation needed]
Demineralization is the opposite process of mineralization; it is a process of reduction in the mineral content in tissue or an organism. Examples include bone demineralization or tooth demineralization. Demineralization can lead to serious diseases such as osteoporosis, rickets, or tooth decay. [1]
Fossil skeletal parts from extinct belemnite cephalopods of the Jurassic – these contain mineralized calcite and aragonite.. Biomineralization, also written biomineralisation, is the process by which living organisms produce minerals, [a] often resulting in hardened or stiffened mineralized tissues.
Mineralization may refer to: Biomineralization (mineralization in biology), when an inorganic substance precipitates in an organic matrix Mineralized tissues are tissues that have undergone mineralization, including bones, teeth, antlers, and marine shells Bone remodeling, involving demineralization and remineralization in bones
Demineralisation or demineralization may refer to: Demineralization (physiology) Bone demineralisation leading to osteoporosis; see Bone mineralization; Tooth demineralisation that leads to dental caries; see Remineralisation of teeth; Demineralizing (silk worm cocoon)
Skeletonization is the state of a dead organism after undergoing decomposition. [1] Skeletonization refers to the final stage of decomposition, during which the last vestiges of the soft tissues of a corpse or carcass have decayed or dried to the point that the skeleton is exposed.
The cells of our bone that is involved in bone formation and bone breakdown is osteoblast and osteoclast respectively. Osteoclasts are cells of bones that promote bone demineralization or bone resorption. [3] In contrast, Osteoblast promotes calcium absorption by the bone therefore, promoting bone mineralization and formation of new bones. [2]