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2. Fexofenadine - Wikipedia

   en.wikipedia.org/wiki/Fexofenadine

   The safety profile of fexofenadine is quite favorable, as no cardiovascular or sedative effects have been shown to occur even when taking 10 times the recommended dose. [25] Research on humans ranges from a single 800-mg dose, to a twice-daily, 690-mg dose for a month, with no clinically significant adverse effects, when compared to a placebo.

3. H1 antagonist - Wikipedia

   en.wikipedia.org/wiki/H1_antagonist

   50 mg 2–3 hours 2–9 hours CYP2D6, others Yes Doxylamine: 25 mg 2–3 hours 10–12 hours CYP2D6, others Yes Hydroxyzine: 25–100 mg 2 hours 20 hours ADH, CYP3A4, others No Doxepin: 3–6 mg 2–3 hours 17 hours c: CYP2D6, others No (at low doses) Mirtazapine: 7.5–15 mg 2 hours 20–40 hours CYP2D6, others No Quetiapine e: 25–200 mg 1.5 ...

4. Fexofenadine/pseudoephedrine - Wikipedia

   en.wikipedia.org/wiki/Fexofenadine/pseudoephedrine

   It contains fexofenadine, as the hydrochloride, an antihistamine; and pseudoephedrine, as the hydrochloride, a nasal decongestant. [ 2 ] In 2021, it was the 279th most commonly prescribed medication in the United States, with more than 800,000 prescriptions.

5. Terfenadine - Wikipedia

   en.wikipedia.org/wiki/Terfenadine

   Terfenadine acts as a peripherally-selective antihistamine, or antagonist of the histamine H 1 receptor. [3] It is a prodrug, generally completely metabolized to the active form fexofenadine in the liver by the enzyme cytochrome P450 3A4. Due to its near complete metabolism by the liver immediately after leaving the gut, terfenadine normally is ...

6. Equianalgesic - Wikipedia

   en.wikipedia.org/wiki/Equianalgesic

   An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]

7. Antihistamine - Wikipedia

   en.wikipedia.org/wiki/Antihistamine

   H 1-antihistamines work by binding to histamine H 1 receptors in mast cells, smooth muscle, and endothelium in the body as well as in the tuberomammillary nucleus in the brain. Antihistamines that target the histamine H 1 -receptor are used to treat allergic reactions in the nose (e.g., itching, runny nose, and sneezing).

8. H2 receptor antagonist - Wikipedia

   en.wikipedia.org/wiki/H2_receptor_antagonist

   Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.

9. Ceiling effect (pharmacology) - Wikipedia

   en.wikipedia.org/wiki/Ceiling_effect_(pharmacology)

   [1] Sometimes drugs cannot be compared across a wide range of treatment situations because one drug has a ceiling effect. [citation needed] Sometimes the desired effect increases with dose, but side-effects worsen or start being dangerous, and risk to benefit ratio increases. This is because of occupation of all the receptors in a given specimen.