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The IFIT family is commonly induced by type I and type III interferon. [3] [5] IFIT gene expression has been observed in response to both DNA and RNA viral infection. IFIT genes suppress viral infection primarily by limiting viral RNA and DNA replication. [5] IFIT proteins 1,2,3 and 5 can bind directly to double-stranded triphosphate RNA.
These Interferon Regulated Genes are also known as Interferon Stimulated Genes (ISGs). The database contains information on type I (IFN alpha, beta), type II (IFN gamma) and type III (IFN lambda) regulated genes and is regularly updated. It is used by the interferon and cytokine research community [2] both as an analysis tool and an information ...
The gene encoding IFNα2, the IFNA2 gene, is clustered with all other type I IFN genes on chromosome 9 [8] and as all type I IFN genes, it is devoid of intron. [9] The open reading frame (coding sequence) of IFNA2 codes for a pre-protein of 188 amino acids with a 23 amino acid signal peptide allowing secretion of the mature protein. The mature ...
Interferon-stimulated gene 15 (ISG15) is a 17 kDa secreted protein that in humans is encoded by the ISG15 gene. [ 5 ] [ 6 ] ISG15 is induced by type I interferon (IFN) and serves many functions, acting both as an extracellular cytokine and an intracellular protein modifier.
IFNAR agonism results in transcriptional changes, with the potential to increase or suppress the transcription of over 2000 different genes. [9] For example, type I IFNs induce interferon-stimulated gene expression, classically resulting in a robust anti-viral immune
Interferon-induced protein with tetratricopeptide repeats 2 (commonly termed IFIT2) is a protein that in humans is directed to be produced by the IFIT2 gene. [5] [6] [7] Previously, this gene was termed the G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, or P54 gene and the protein that it directs to be produced was termed the G10P2, GARG-39, IFI-54, IFI-54K, IFI54 ...
15959 Ensembl ENSG00000119917 ENSMUSG00000074896 UniProt O14879 Q64345 RefSeq (mRNA) NM_001549 NM_001031683 NM_001289758 NM_001289759 NM_010501 RefSeq (protein) NP_001026853 NP_001276687 NP_001276688 NP_001540 NP_034631 Location (UCSC) Chr 10: 89.33 – 89.38 Mb Chr 19: 34.56 – 34.57 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interferon-induced protein with tetratricopeptide ...
Viperin is an interferon-stimulated gene whose expression inhibits many DNA and RNA viruses including CHIKV, HCMV, HCV, DENV, WNV, SINV, influenza, and HIV. [6] Initially identified as an IFN-γ induced antiviral protein in human cytomegalovirus (HCMV) infected macrophages, it was reported that viperin could be induced by HCMV glycoprotein B in fibroblasts, but inhibits HCMV viral infection ...