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Aplastic anemia is a rare, noncancerous disorder in which the blood marrow is unable to adequately produce blood cells required for survival. [44] [45] It is estimated that the incidence of aplastic anemia is 0.7–4.1 cases per million people worldwide, with the prevalence between men and women being approximately equal. [46]
With isolated reticulocytopenia, the main cause is Parvovirus B19 infection of reticulocytes leading to transient anemia. [2] In patients who rely on frequent red cell regeneration e.g. sickle cell disease, a reticulocytopenia can lead to a severe anemia due to the cessation in red cell production (erythropoiesis), referred to as aplastic ...
Stem cell researcher Pluristem Therapeutics announced that the FDA granted its patented PLacental eXpanded (PLX) cells orphan drug status for the treatment of aplastic anemia, a rare disorder ...
Microangiopathic hemolytic anemia; Secondary to artificial heart valve(s) Aplastic anemia. Fanconi anemia; Diamond–Blackfan anemia (inherited pure red cell aplasia) Acquired pure red cell aplasia; Decreased numbers of cells. Myelodysplastic syndrome; Myelofibrosis; Neutropenia (decrease in the number of neutrophils) Agranulocytosis; Glanzmann ...
While acquired aplastic anemia with an unknown cause is rare, it is commonly permanent and life-threatening as half of those with this condition die within the first six months. [10] The prevalence of bone marrow failure is over three times higher in Japan and East Asia than in the United States and Europe. [10]
Danicopan, sold under the brand name Voydeya, is a medication used for the treatment of paroxysmal nocturnal hemoglobinuria. It is a complement inhibitor which reversibly binds to factor D to prevent alternative pathway-mediated hemolysis and deposition of complement C3 proteins on red blood cells. The most common side effects include fever, headache, increased levels of liver enzymes (a sign ...
This is termed "aplastic crisis" (also called reticulocytopenia). It is treated with blood transfusion. Parvovirus B19 is a cause of chronic anemia in individuals with immunodeficiency, receiving immunosuppressive therapy or with HIV infection. Treatment with intravenous immunoglobulin usually resolves the anemia although relapse can occur.
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