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Dapagliflozin is used along with diet, exercise, and usually with other glucose-lowering medications, to improve glycaemic control in adults with type 2 diabetes. . Dapagliflozin, in addition to other SGLT2-inhibitors, was shown to reduce the rate of decline in kidney function and kidney failure in non-diabetic and type 2 diabetic adults when added to the existing treatment
It contains dapagliflozin, as propanediol monohydrate, a SGLT-2 inhibitor; and sitagliptin, as phosphate monohydrate, a DPP-4 inhibitor. [1] It is taken by mouth . [ 1 ]
10.6 (100 mg dose); 13.1 (300 mg dose) 1096 ng/mL (100 mg dose); 3480 ng/mL (300 mg dose) 250 fold Dapagliflozin: 78%: 91%: 1–1.5: 12.9: 79.6 ng/mL (5 mg dose); 165.0 ng/mL (10 mg dose) 1200 fold Empagliflozin: 90–97% (mice); 89% (dogs); 31% (rats) 86.20%: 1.5: 13.2 (10 mg dose); 13.3h (25 mg dose) 259nmol/L (10 mg dose); 687nmol/L (25 mg dose)
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Dapagliflozin/metformin was approved for use in the European Union in January 2014, [3] in the United States in February 2014, [5] [6] and in Australia in July 2014. [7]
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