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Prednisone is a synthetic glucocorticoid used for its anti-inflammatory and immunosuppressive properties. [36] [37] Prednisone is a prodrug; it is metabolised in the liver by 11-β-HSD to prednisolone, the active drug. Prednisone has no substantial biological effects until converted via hepatic metabolism to prednisolone. [38]
[7] [8] [6] It differs from the similarly named prednisone in having a hydroxyl at the 11th carbon instead of a ketone. Common side effects with short-term use include nausea, difficulty concentrating, insomnia, increased appetite, and fatigue. [5] More severe side effects include psychiatric problems, which may occur in about 5% of people. [9]
Troleandomycin, ketoconazole, and Clarithromycin inhibit metabolism; and may decrease the rate of elimination and increase the half-life of methylprednisolone. [21] [32] Dosages should be decreased accordingly to avoid side effects. Another CYP 3A4 inhibitor, grapefruit juice, prolongs the half-life of oral methylprednisolone. [32]
Deflazacort's potency is around 70–90% that of prednisone. [8] A 2017 review found its activity of 7.5 mg of deflazacort is approximately equivalent to 25 mg cortisone , 20 mg hydrocortisone , 5 mg of prednisolone or prednisone , 4 mg of methylprednisolone or triamcinolone , or 0.75 mg of betamethasone or dexamethasone .
Common side effects of fludrocortisone include high blood pressure, swelling, heart failure, and low blood potassium. [3] Other serious side effects can include low immune-system function, cataracts, muscle weakness, and mood changes. [3] Whether use of fludrocortisone during pregnancy is safe for the fetus is unknown. [5]
Escitalopram Half-Life Escitalopram has a half-life of 27 to 32 hours . In other words, if you take a dose of 10mg of Lexapro, only 5mg will remain in your bloodstream after 27 to 32 hours.
Consuming more than 45% of daily calories after 5 p.m. can contribute to greater risk of type 2 diabetes, cardiovascular problems, and chronic inflammation, a recent study suggests.
Steroidogenesis.Trilostane inhibits 3β-HSD. Trilostane is a steroidogenesis inhibitor. [1] It is specifically an inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD). [1] [15] As a result of this action, trilostane blocks the conversion of Δ 5-3β-hydroxysteroids, including pregnenolone, 17α-hydroxypregnenolone, dehydroepiandrosterone (DHEA), and androstenediol, into Δ 4-3-ketosteroids ...
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