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Antipsychotics by class Generic name Brand names Chemical class ATC code Typical antipsychotics; Acepromazine: Atravet, Acezine: phenothiazine: N05AA04
The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), [1] [2] are a group of antipsychotic drugs (antipsychotic drugs in general are also known as tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) largely introduced after the 1970s and used to treat psychiatric ...
The mechanism of actions of most antipsychotics is post-synaptic blockage of brain dopamine D2 receptors. Second generation antipsychotics also bind with serotonin 5HT2 receptors at a high affinity, which is suggested to be the cause for the lowered risk of extrapyramidal side effects compared with first generation antipsychotics. [14]
Antipsychotics work best in the manic phase of bipolar disorder. [20] Second-generation or atypical antipsychotics (including aripiprazole , olanzapine , quetiapine , paliperidone , risperidone , and ziprasidone ) have emerged as effective mood stabilizers. [ 2 ]
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Typical antipsychotics (also known as major tranquilizers, and first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia). Typical antipsychotics may also be used for the treatment of acute mania, agitation, and other conditions.
Atypical antipsychotics, such as clozapine block both the D2 Dopamine receptors as well as 5HT2A serotonin receptors. Atypical antipsychotics are favored over conventional antipsychotics because they reduce the prevalence of pseudoparkinsonism which causes tremors and muscular rigidity similar to Parkinson's disease.
The NYPD has added more than three dozen new names to its memorial honoring officers who died in the line of duty — with Mayor Eric Adams saying the fallen watered “the tree of freedom” with ...