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Haemophilia (British English), or hemophilia (American English) [6] (from Ancient Greek αἷμα (haîma) 'blood' and φιλία (philía) 'love of'), [7] is a mostly inherited genetic disorder that impairs the body's ability to make blood clots, a process needed to stop bleeding.
H. Influenzae type b, also known as Hib, is the most common form, recognizable by its polyribosyl ribitol phosphate (PRP) capsule, and found mostly in children. [24] Types a, e, and f have been isolated infrequently, while types d and c are rarely isolated. Unencapsulated strains are more genetically diverse than the encapsulated group. [25]
The incidences reported below are from the full report, though the rates may vary in different populations. [2] Blood cell disorders. Sickle cell anemia (Hb SS) > 1 in 5,000; among African-Americans 1 in 400; Sickle-cell disease (Hb S/C) > 1 in 25,000; Hb S/Beta-Thalassemia (Hb S/Th) > 1 in 50,000; Inborn errors of amino acid metabolism
Animals avoid inbreeding only rarely. [2] Inbreeding results in homozygosity which can increase the chances of offspring being affected by recessive traits. [3] In extreme cases, this usually leads to at least temporarily decreased biological fitness of a population [4] [5] (called inbreeding depression), which
Based on 2005-2006 estimates, the Centers for Disease Control and Prevention has stated that approximately 5.5 million Americans a year are either admitted to a hospital or seen by a physician, with some form of anemia as their primary diagnosis. [4] Symptoms of anaemia include Plummer–Vinson syndrome, candidal infections.
The price is less than the $3.5 million announced last year for a similar gene therapy for hemophilia B, a less common form of the disease. Like most medicines in the U.S., the new treatment will ...
The term "Rh Disease" is commonly used to refer to HDFN due to anti-D antibodies, and prior to the discovery of anti-Rh o (D) immune globulin, it was the most common type of HDFN. The disease ranges from mild to severe, and occurs in the second or subsequent pregnancies of Rh-D negative women when the biologic father is Rh-D positive.
Before modern times, children born with CF would have a life expectancy of only a few years, but modern medicine has made it possible for these people to live into adulthood. However, even in these individuals, CF typically causes male infertility. It is the most common genetic disease among people of European descent.