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  2. Stimuli-responsive drug delivery systems - Wikipedia

    en.wikipedia.org/wiki/Stimuli-responsive_drug...

    Conventional drug delivery is limited by the inability to control dosing, target specific sites, and achieve targeted permeability. Traditional methods of delivering therapeutics to the body experience challenges in achieving and maintaining maximum therapeutic effect while avoiding the effects of drug toxicity.

  3. Modified-release dosage - Wikipedia

    en.wikipedia.org/wiki/Modified-release_dosage

    Using an osmotic pump to deliver drugs has additional inherent advantages regarding control over drug delivery rates. This allows for much more precise drug delivery over an extended period of time, which results in much more predictable pharmacokinetics. However, osmotic release systems are relatively complicated, somewhat difficult to ...

  4. Drug delivery - Wikipedia

    en.wikipedia.org/wiki/Drug_delivery

    A 2013 review found the cost of developing a delivery system was only 10% of the cost of developing a new pharmaceutical. [16] A more recent study found the median cost of bringing a new drug to market was $985 million in 2020, but did not look at the cost of developing drug delivery systems. [17]

  5. Osmotic-controlled release oral delivery system - Wikipedia

    en.wikipedia.org/wiki/Osmotic-controlled_Release...

    The drug is expelled via the laser-drilled hole visible on the left side of the tablet. The osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it.

  6. Nanoparticle drug delivery - Wikipedia

    en.wikipedia.org/wiki/Nanoparticle_drug_delivery

    Controlled drug release systems can be achieved through several methods. Rate-programmed drug delivery systems are tuned to the diffusivity of active agents across the membrane. [44] Another delivery-release mechanism is activation-modulated drug delivery, where the release is triggered by environmental stimuli.

  7. PH-responsive tumor-targeted drug delivery - Wikipedia

    en.wikipedia.org/wiki/PH-responsive_tumor...

    pH-triggered drug delivery systems are able to control the pharmacokinetics and the biodistribution of the drugs enclosed within the drug carrier and have a controlled release. Many “smart” pH-responsive drug delivery systems have not made it to clinical trials. [27] However, there still are many challenges with this treatment method. [10]

  8. Transdermal patch - Wikipedia

    en.wikipedia.org/wiki/Transdermal_patch

    An advantage of a transdermal drug delivery route over other types of medication delivery (such as oral, topical, intravenous, or intramuscular) is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers ...

  9. Gated drug delivery systems - Wikipedia

    en.wikipedia.org/wiki/Gated_drug_delivery_systems

    The history of gated drug delivery systems starts in the mid-1960s when the concept of zero order controlled drug delivery was first thought of. Researchers raced to be able to find a drug delivery platform that would be able to have perfectly sustained drug release.

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