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  2. Thrombin - Wikipedia

    en.wikipedia.org/wiki/Thrombin

    Thrombin (Factor IIa) (EC 3.4.21.5, fibrose, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, that converts fibrinogen into strands of insoluble fibrin, as well as catalyzing many other coagulation-related reactions.

  3. Coagulation - Wikipedia

    en.wikipedia.org/wiki/Coagulation

    Coagulation factor concentrates are used to treat hemophilia, to reverse the effects of anticoagulants, and to treat bleeding in people with impaired coagulation factor synthesis or increased consumption. Prothrombin complex concentrate, cryoprecipitate and fresh frozen plasma are commonly used coagulation factor products.

  4. Coagulation activation marker - Wikipedia

    en.wikipedia.org/wiki/Coagulation_activation_marker

    Coagulation activation markers are biomarkers of net activation of coagulation and fibrinolysis. [ 1 ] [ 2 ] Examples include prothrombin fragment 1+2 (F1+2), thrombin–antithrombin complex (TAT), fibrinopeptide A (FpA), fibrin monomers (FMs), plasmin-α 2 -antiplasmin complex (PAP), activated protein C–protein C inhibitor (APC-PCI), and D ...

  5. Prothrombin G20210A - Wikipedia

    en.wikipedia.org/wiki/Prothrombin_G20210A

    Prothrombin G20210A is a genotypic trait that provides a prompter coagulation response. It increases the risk of blood clots including from deep vein thrombosis , and of pulmonary embolism . [ 1 ] One copy of the mutation increases the risk of a blood clot from 1 in 1,000 per year to 2.5 in 1,000. [ 1 ]

  6. Prothrombinase - Wikipedia

    en.wikipedia.org/wiki/Prothrombinase

    The prothrombinase complex catalyzes the conversion of prothrombin (factor II), an inactive zymogen, to thrombin (factor IIa), an active serine protease. The activation of thrombin is a critical reaction in the coagulation cascade , which functions to regulate hemostasis in the body.

  7. Proteinase-activated receptor 1 - Wikipedia

    en.wikipedia.org/wiki/Proteinase-activated...

    Proteinase-activated receptor 1 (PAR1) also known as protease-activated receptor 1, coagulation factor II receptor and thrombin receptor is a protein that in humans is encoded by the F2R gene. [5] PAR1 is a G protein-coupled receptor and one of four protease-activated receptors involved in the regulation of thrombotic response.

  8. A Rhode Island man has admitted to using gasoline to set several fires around the exterior of a predominantly Black church earlier this year, according to a federal plea agreement.

  9. Direct thrombin inhibitor - Wikipedia

    en.wikipedia.org/wiki/Direct_thrombin_inhibitor

    Direct thrombin inhibitors (DTIs) are a class of medication that act as anticoagulants (delaying blood clotting) by directly inhibiting the enzyme thrombin (factor IIa). Some are in clinical use, while others are undergoing clinical development.

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