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The effects of rosuvastatin on low-density lipoprotein (LDL) cholesterol are dose-related. Higher doses were more efficacious in improving the lipid profile of patients with hypercholesterolemia than milligram-equivalent doses of atorvastatin and milligram-equivalent or higher doses of simvastatin and pravastatin.
The most important adverse side effects are muscle problems, an increased risk of diabetes mellitus, and increased liver enzymes in the blood due to liver damage. [ 5 ] [ 65 ] Over 5 years of treatment statins result in 75 cases of diabetes, 7.5 cases of bleeding stroke , and 5 cases of muscle damage per 10,000 people treated. [ 34 ]
Crestor typically does have a slightly positive impact on HDL levels, though this is qujite low compared to, say, nicotinic acid. This is across all does ranges. For comparison, simvastatin is neutral to slightly positive, and atorvastatin (anecdotally) appears to be dose-dependant; low doses slightly lower HDL, while higher doses increase it ...
Dyslipidemia is when the lipids in your blood are too high or too low. Estimates suggest that 53 percent of adults in the U.S. have lipid abnormalities.. Lipids are a type of fat that make up the ...
JUPITER was a randomized double-blind placebo-controlled study investigating the use of rosuvastatin in the primary prevention of cardiovascular disease.The trial focused on patients with normal low-density lipoprotein (LDL) cholesterol levels but increased levels of high-sensitivity C-reactive protein (hs-CRP).
Potential risks: Some negative side effects like muscle cramps, facial swelling, and bloating have been reported in relation to medication interactions, as well as for some people with existing ...
The median effective dose is the dose that produces a quantal effect (all or nothing) in 50% of the population that takes it (median referring to the 50% population base). [6] It is also sometimes abbreviated as the ED 50, meaning "effective dose for 50% of the population". The ED50 is commonly used as a measure of the reasonable expectancy of ...
There are a few possible side effects linked to taking NSAIDs, including: gastrointestinal problems (such as irritation, ulcers, or bleeding), increased risk of heart attack and stroke, reduced ...
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