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Frequency. 1 in 1,000–10,000. Sudden infant death syndrome (SIDS), sometimes known as cot death, is the sudden unexplained death of a child of less than one year of age. Diagnosis requires that the death remain unexplained even after a thorough autopsy and detailed death scene investigation. [2] SIDS usually occurs during sleep. [3]
Hematology. X-linked severe combined immunodeficiency (X-SCID) is an immunodeficiency disorder in which the body produces very few T cells and NK cells. In the absence of T cell help, B cells become defective. [ 1 ] It is an X-linked recessive inheritance trait, stemming from a mutated (abnormal) version of the IL2RG gene located on the X ...
SUDC is similar in concept to sudden infant death syndrome (SIDS). Like SIDS, SUDC is a diagnosis of exclusion, the concrete symptom of both being death. However, SIDS is a diagnosis specifically for infants under the age of 12 months while SUDC is a diagnosis for children 12 months and older.
Primary CNS lymphoma is highly associated with Epstein-Barr virus (EBV) infection (> 90%) in immunodeficient patients (such as those with AIDS and those immunosuppressed), [4] and does not have a predilection for any particular age group. Mean CD4 + count at time of diagnosis is ~50/μL. In immunocompromised patients, prognosis is usually poor.
The second-most common cancer is lymphoma, which is the cause of death of nearly 16% of people with AIDS and is the initial sign of AIDS in 3% to 4%. [42] Both these cancers are associated with human herpesvirus 8 (HHV-8). [42] Cervical cancer occurs more frequently in those with AIDS because of its association with human papillomavirus (HPV). [42]
B symptoms include: Fever greater than 38 °C. Pel–Ebstein fever, the classic intermittent fever associated with Hodgkin disease, occurs at variable intervals of days to weeks and lasts for 1–2 weeks before resolving. However, fever associated with lymphoma can follow virtually any pattern. Drenching sweats, especially at night.
Hodgkin lymphoma (HL) is a type of lymphoma in which cancer originates from a specific type of white blood cell called lymphocytes, where multinucleated Reed–Sternberg cells (RS cells) are present in the patient's lymph nodes. [2][8] The condition was named after the English physician Thomas Hodgkin, who first described it in 1832. [9][10 ...
Paraneoplastic syndrome. A paraneoplastic syndrome is a syndrome (a set of signs and symptoms) that is the consequence of a tumor in the body (usually a cancerous one). [1] It is specifically due to the production of chemical signaling molecules (such as hormones or cytokines) by tumor cells or by an immune response against the tumor. [2]
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