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Gadolinium (III) containing MRI contrast agents (often termed simply "gado" or "gad") are the most commonly used for enhancement of vessels in MR angiography or for brain tumor enhancement associated with the degradation of the blood–brain barrier (BBB). [3][4] Over 450 million doses have been administered worldwide from 1988 to 2017. [5]
MRI provides excellent soft tissue contrast and is widely used in theranostics for its ability to visualize anatomical structures and assess physiological processes. [ 8 ] In theranostics, MRI allows for the detection and characterization of tumors, assessment of tumor extent, and evaluation of treatment response.
MRI without contrast agents is the imaging mode of choice for pre-surgical, in-utero diagnosis and evaluation of fetal tumors, primarily teratomas, facilitating open fetal surgery, other fetal interventions, and planning for procedures (such as the EXIT procedure) to safely deliver and treat babies whose defects would otherwise be fatal.
Most side effects are predictable and expected. Side effects from radiation are usually limited to the area of the patient's body that is under treatment. Side effects are dose-dependent; for example, higher doses of head and neck radiation can be associated with cardiovascular complications, thyroid dysfunction, and pituitary axis dysfunction ...
A contrast agent(or contrast medium) is a substanceused to increase the contrastof structures or fluids within the body in medical imaging.[1] Contrast agents absorb or alter external electromagnetismor ultrasound, which is different from radiopharmaceuticals, which emit radiationthemselves. In X-rayimaging, contrast agents enhance the ...
Iodinated contrast contains iodine.It is the main type of radiocontrast used for intravenous administration.Iodine has a particular advantage as a contrast agent for radiography because its innermost electron ("k-shell") binding energy is 33.2 keV, similar to the average energy of x-rays used in diagnostic radiography.
Iodinated contrast. Contrast CT of a patient with brain metastases from breast cancer, before (left) and after (right) injection of iodinated contrast. Iodinated contrast is a form of water-soluble, intravenous radiocontrast agent containing iodine, which enhances the visibility of vascular structures and organs during radiographic procedures.
Gadoteric acid, sold under the brand name Dotarem among others, is a macrocycle -structured gadolinium-based MRI contrast agent (GBCA). It consists of the organic acid DOTA as a chelating agent, and gadolinium (Gd 3+), and is used in form of the meglumine salt (gadoterate meglumine). [4][5] The paramagnetic property of gadoteric acid reduces ...