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Calcipotriol, also known as calcipotriene, is a synthetic derivative of calcitriol, a form of vitamin D. It is used in the treatment of psoriasis. [1] It is safe for long-term application in psoriatic skin conditions. [medical citation needed] It was patented in 1985 and approved for medical use in 1991. [2]
[8] [23] The ointment and topical suspension formulation (Daivobet) were also approved in 2010 by the European Medicines Agency for the treatment of plaque psoriasis where it is possible to use a topical medication (ointment), and for the treatment of scalp psoriasis or mild to moderate plaque psoriasis on the body (topical suspension). [24]
Tacalcitol (1,24-dihydroxyvitamin D 3) is a synthetic vitamin D 3 analog. [1] Tacalcitol is marketed under several names, including Curatoderm and Bonalfa. It is on the World Health Organization's List of Essential Medicines. [2]
The natural, active form of vitamin D is calcitriol (1,25-dihydroxycholecalciferol). This molecule and other naturally occurring forms of vitamin D, including its precursors and metabolites, have been modified to synthesize pharmaceuticals with potentially greater, or selective, therapeutic actions. [1] [2] [3] [4]
Vitamin D analogs may be useful with steroids; steroids alone have a higher rate of side effects. [81] Vitamin D analogs may allow lower doses of steroids to be used. [85] Another topical therapy used to treat psoriasis is a form of balneotherapy, which involves daily baths in saltwater, such as the Dead Sea, combined with sun exposure. This is ...
synthetic (sDMARD) conventional synthetic and targeted synthetic DMARDs (csDMARDs and tsDMARDs, respectively) csDMARDs are the traditional drugs (such as methotrexate, sulfasalazine, leflunomide, hydroxychloroquine, gold salts) tsDMARDs are drugs that were developed to target a particular molecular structure
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