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Oleylamine reacts with carboxylic acid to form its carboxylate salt through an exothermic reaction. [8] [9] Its carboxylate salt can further condensate into amides through the loss of one water molecule. In the presence of acetic acid, oleylamin forms with DNA insoluble complexes with the radii of the particles equal 60–65 nm. [10]
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Fatty amines are commonly prepared from fatty acids; which are themselves obtained from natural sources, typically seed-oils.The overall reaction is sometimes referred to as the Nitrile Process [3] and begins with a reaction between the fatty acid and ammonia at high temperature (>250 °C) and in the presence of a metal oxide catalyst (e.g., alumina or zinc oxide) to give the fatty nitrile.
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Hydroxylamine can also be used to highly selectively cleave asparaginyl-glycine peptide bonds in peptides and proteins. [32] It also bonds to and permanently disables (poisons) heme-containing enzymes. It is used as an irreversible inhibitor of the oxygen-evolving complex of photosynthesis on account of its similar structure to water.
Oleamide has been found in Ziziphus jujuba, also known as Jujube fruit. [14]Synthetic oleamide has a variety of industrial uses, including as a lubricant. [15]Oleamide was found to be leaching out of polypropylene plastics in laboratory experiments, affecting experimental results. [16]
SM-102 is a synthetic amino lipid which is used in combination with other lipids to form lipid nanoparticles. [1] These are used for the delivery of mRNA-based vaccines, [2] [3] [4] and in particular SM-102 forms part of the drug delivery system for the Moderna COVID-19 vaccine.
Hydroxyethyl cellulose is a gelling and thickening agent derived from cellulose. It is widely used in cosmetics, cleaning solutions, and other household products. [ 1 ] Hydroxyethyl cellulose and methyl cellulose are frequently used with hydrophobic drugs in capsule formulations, to improve the drugs' dissolution in the gastrointestinal fluids.