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U.S. Route 221 (US 221) is a part of the U.S. Highway System that runs from Perry, Florida to Lynchburg, Virginia.In Virginia, the U.S. Highway runs 149.61 miles (240.77 km) from the North Carolina state line near Independence north to its northern terminus at US 29 Business, US 460 Business, and US 501 Business in Lynchburg.
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SR 151 south (Critzers Shop Road) – Lynchburg, Wintergreen, Wintergreen Resort, truck route to SR 6: Northern terminus of SR 151 SR 690 (Greenwood Road / Ortman Road) SR 691 (Greenwood Station Road) – Greenwood: Southern terminus of SR 691: Yancey Mills: 81.12: 130.55: I-64 – Staunton, Richmond: Exit 107 (I-64) Brownsville: 82.81: 133.27
US 29 (N & S Amherst Hwy, S. Amherst Hwy is US BUS 29 south of Amherst and then turns into the Lynchburg Expressway in Madison Heights; Monacan Trail) US 60 (Lexington Turnpike; Richmond Hwy) US 501 (joins SR 130 and becomes Elon Rd.) SR 130 (Elon Rd; Amelon Hwy) SR 151 (Patrick Henry Hwy) SR 163 (S Amherst Hwy) SR 210 (Old Town Connector)
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SR 151 south (Patrick Henry Highway) – Piney River, Lynchburg: Eastern end of SR 151 concurrency SR 655 (Roseland Road) – Roseland: former planned SR 56 west: Colleen: 31.28: 50.34: US 29 south (Thomas Nelson Highway) – Lynchburg: Western end of US 29 concurrency 35.56: 57.23: US 29 north (Thomas Nelson Highway) – Charlottesville
The Piedmont region of Virginia is a part of the greater Piedmont physiographic region which stretches from the falls of the Potomac, Rappahannock, and James Rivers to the Blue Ridge Mountains. The region runs across the middle of the state from north to south, expanding outward to a width of nearly 190 miles at the border with North Carolina .
East of SR 49 (Watsons Wood Road), the two highways reduce to a two-lane road with center turn lane and parallel the Crewe rail yard that separates Norfolk Southern's Blue Ridge and Norfolk districts. In the center of town, SR 49 splits south onto The Falls Road. US 460 expands back to a four-lane divided highway at the east end of town.