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Gabapentin reduces spasticity in multiple sclerosis and is prescribed as one of the first-line options. [54] It is an established treatment of restless legs syndrome. [55] Gabapentin alleviates itching in kidney failure (uremic pruritus) [56] [57] and itching of other causes. [58] It may be an option in essential or orthostatic tremor. [59] [60 ...
When used off-label, gabapentin can treat a large range of conditions and their symptoms according to the NIH (National Institutes of Health), including: Fibromyalgia Anxiety
Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. [1] There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity.
Pregabalin and gabapentin are analogues of gamma-aminobutyric acid that modulate neurotransmitters, possibly through reducing the release of neurotransmitters. [21] Numerous pruritic disorders, including brachioradial pruritus and pruritus in patients with diabetic neuropathic pain, have been linked to the neuropathic role in their pathogenesis ...
The oral bioavailability of gabapentin enacarbil (as gabapentin) is greater than or equal to 68%, across all doses assessed (up to 2,800 mg), with a mean of approximately 75%. [ 25 ] [ 1 ] In contrast to the other gabapentinoids, the pharmacokinetics of phenibut have been little-studied, and its oral bioavailability is unknown. [ 28 ]
The term usually refers to damage induced by excessive use of combinations of these medications, especially combinations that include phenacetin. It may also be used to describe kidney injury from any single analgesic medication. The specific kidney injuries induced by analgesics are renal papillary necrosis and chronic interstitial nephritis.
Nephritis can often be caused by infections and toxins, but it is most commonly caused by autoimmune disorders that affect the major organs like kidneys. [ 5 ] Pyelonephritis is inflammation that results from a urinary tract infection that reaches the renal pelvis of the kidney.
Kidney disease, or renal disease, technically referred to as nephropathy, is damage to or disease of a kidney. Nephritis is an inflammatory kidney disease and has several types according to the location of the inflammation. Inflammation can be diagnosed by blood tests.
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