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Moxidectin is an anthelmintic drug used in animals to prevent or control parasitic worms , such as heartworm and intestinal worms, in dogs, cats, horses, cattle, sheep and wombats. [4] Moxidectin kills some of the most common internal and external parasites by selectively binding to a parasite's glutamate-gated chloride ion channels.
Mature horses appear to develop a certain degree of resistance to this parasite, but it is a concern for younger horses up to about two years old. [4] P. equorum is one of the few parasites where a natural immunity develops in the host. [3] However, when an infection is found in an adult horse, both the worm and egg counts are substantially low ...
Oxfendazole is an anthelmintic (wormer) compound used in veterinary practice. It comes under the chemical class of the benzimidazoles. This drug is barely used in horses, [3] goats, sheep, and cattle. It is very scarcely applied on dogs and cats.
All major gastrointestinal nematode genera survived treatment in various studies. In cattle, prevalence of anthelminthic resistance varied between anthelmintic classes from 0–100% (benzimidazoles and macrocyclic lactones), 0–17% (levamisole) and 0–73% (moxidectin), and both Cooperia and Ostertagia survived treatment. [14]
Continuous dewormers are a mild low dose and may be easier on the horse, but may not be effective in quickly killing worms in a heavily-infected horse and may contribute to drug resistance. If a treatment doesn't kill at least 95% of a worm species, that species is classed as 'resistant' to the drug.
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Levamisole has gained prominence among aquarists as an effective treatment for Camallanus roundworm infestations in freshwater tropical fish. [9] Levamisole has been used to treat small ruminant animals since the late 1960s. [10] Levamisole-resistant parasitic worms are common in sheep farms in New Zealand, [11] Uruguay, [12] Paraguay, [13] and ...
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