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  2. What is gabapentin? Here's why it's so controversial. - AOL

    www.aol.com/news/gabapentin-heres-why...

    Gabapentin is a prescription medication that was approved by the U.S. Food and Drug Administration in 1993 as a treatment for epilepsy. It works by binding to a type of calcium channel in nerve ...

  3. Gabapentin - Wikipedia

    en.wikipedia.org/wiki/Gabapentin

    Gabapentin does not bind to other drug transporters such as P-glycoprotein (ABCB1) or OCTN2 (SLC22A5). [95] It is not significantly bound to plasma proteins (<1%). [94] Gabapentin undergoes little or no metabolism. [86] [94] Gabapentin is generally safe in people with liver cirrhosis. [99] Gabapentin is eliminated renally in the urine. [94]

  4. Gabapentinoid - Wikipedia

    en.wikipedia.org/wiki/Gabapentinoid

    The oral bioavailability of gabapentin enacarbil (as gabapentin) is greater than or equal to 68%, across all doses assessed (up to 2,800 mg), with a mean of approximately 75%. [ 25 ] [ 1 ] In contrast to the other gabapentinoids, the pharmacokinetics of phenibut have been little-studied, and its oral bioavailability is unknown. [ 28 ]

  5. Gabapentin enacarbil - Wikipedia

    en.wikipedia.org/wiki/Gabapentin_enacarbil

    Gabapentin enacarbil (Horizant (ER) (U.S. Tooltip United States), Regnite (in Japan)) is an anticonvulsant and analgesic drug of the gabapentinoid class, and a prodrug to gabapentin. [1] It was designed for increased oral bioavailability over gabapentin, [ 2 ] [ 3 ] and human trials showed it to produce extended release of gabapentin with ...

  6. Can Gabapentin Really Cause ED? - AOL

    www.aol.com/gabapentin-really-cause-ed-105700638...

    That brings us to gabapentin. If you’re taking gabapentin for any number of reasons — seizures, neuropathic pain, etc. — you likely know what it does. But understandably, you could be ...

  7. Does Adderall Make You Last Longer in Bed or the Opposite? - AOL

    www.aol.com/does-adderall-last-longer-bed...

    If you have dysfunction problems like ED, prescription medication may be a good option to increase stamina. PDE5 inhibitors are ED drugs that can help you get aroused by increasing blood flow to ...

  8. Kindling (sedative–hypnotic withdrawal) - Wikipedia

    en.wikipedia.org/wiki/Kindling_(sedative...

    Binge drinking is believed to increase impulsivity due to altered functioning of prefrontal–subcortical and orbitofrontal circuits. Binge drinking in alcoholics who have undergone repeated detoxification is associated with an inability to interpret facial expressions properly; this is believed to be due to kindling of the amygdala with resultant distortion of neurotransmission.

  9. Why You Feel Bloated and What to Do About It - AOL

    www.aol.com/lifestyle/why-feel-bloated-134900084...

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