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The main source of estrogen is the ovaries in premenopausal women, while in post-menopausal women most of the body's estrogen is produced via the conversion of androgens into estrogen by the aromatase enzyme in the peripheral tissues (i.e. adipose tissue like that of the breast) and a number of sites in the brain. Estrogen is produced locally ...
[1] [2] Other side effects of progestogens may include an increased risk of breast cancer, cardiovascular disease, and blood clots. [2] At high doses, progestogens can cause low sex hormone levels and associated side effects like sexual dysfunction and an increased risk of bone fractures. [3]
Conversely, higher progesterone levels inhibit production of PGF 2α and oxytocin, as the effects of the hormones are in opposition to each other. This is directly exhibited following ovulation when there is a spike of progesterone levels, and then as progesterone levels decrease, PGF 2α levels will peak.
Prostaglandin E 2 (PGE 2), also known as dinoprostone, is a naturally occurring prostaglandin with oxytocic properties that is used as a medication. [2] [3] [4] Dinoprostone is used in labor induction, bleeding after delivery, termination of pregnancy, and in newborn babies to keep the ductus arteriosus open.
Side effects of estradiol valerate include breast tenderness, breast enlargement, nausea, headache, and fluid retention. [15] [13] [14] Estradiol valerate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. [5] [4] [16] It is an estrogen ester and a prodrug of estradiol in the body.
The diversity of receptors means that prostaglandins act on an array of cells and have a wide variety of effects such as: create eicosanoids hormones; act on thermoregulatory center of hypothalamus to produce fever; increase mating behaviors in goldfish [13] cause the uterus to contract [a]
Hormone replacement therapy, consisting of systemic treatment with estrogen alone or in combination with a progestogen, has well-documented and considerable beneficial effects on the skin of postmenopausal people. [70] [71] These benefits include increased skin collagen content, skin thickness and elasticity, and skin hydration and surface lipids.
Hormone replacement therapy consisting of systemic treatment with estrogen alone or in combination with a progestogen, has well-documented and considerable beneficial effects on the skin of postmenopausal women. [25] [26] These benefits include increased skin collagen content, skin thickness and elasticity, and skin hydration and surface lipids.
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