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Calciseptine has been shown to specifically inhibit the L-type voltage-gated Ca 2+ channels and was the first natural polypeptide discovered with this property. Specific polypeptide inhibitors of voltage-sensitive channels are important tools in research, and were already known for voltage-sensitive Na + channels, both voltage-sensitive and Ca 2+-activated K + channels, and for N-type Ca 2 ...
In 2000, after more research was done on α 1 subunits in voltage-gated calcium channels, a new nomenclature was used that called L-type calcium channels CaV1 with its subunits being called CaV1.1, Cav1.2, CaV1.3, and CaV1.4. [3] Research on the CaV1 subunits continues to reveal more about their structure, function, and pharmaceutical ...
857 12389 Ensembl ENSG00000105974 ENSMUSG00000007655 UniProt Q03135 P49817 RefSeq (mRNA) NM_001753 NM_001172895 NM_001172896 NM_001172897 NM_001243064 NM_007616 RefSeq (protein) NP_001166366 NP_001166367 NP_001166368 NP_001744 NP_001229993 NP_031642 Location (UCSC) Chr 7: 116.52 – 116.56 Mb Chr 6: 17.31 – 17.34 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Caveolin-1 is a ...
Cav1.2 is widely expressed in the smooth muscle, pancreatic cells, fibroblasts, and neurons. [ 9 ] [ 10 ] However, it is particularly important and well known for its expression in the heart where it mediates L-type currents, which causes calcium-induced calcium release from the ER Stores via ryanodine receptors .
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779 12292 Ensembl ENSG00000081248 ENSMUSG00000026407 UniProt Q13698 Q02789 RefSeq (mRNA) NM_000069 NM_001081023 NM_014193 RefSeq (protein) NP_000060 NP_001074492 NP_055008 NP_001389878 Location (UCSC) Chr 1: 201.04 – 201.11 Mb Chr 1: 135.98 – 136.05 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Ca v 1.1 also known as the calcium channel, voltage-dependent, L type, alpha 1S ...
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