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Calciseptine has been shown to specifically inhibit the L-type voltage-gated Ca 2+ channels and was the first natural polypeptide discovered with this property. Specific polypeptide inhibitors of voltage-sensitive channels are important tools in research, and were already known for voltage-sensitive Na + channels, both voltage-sensitive and Ca 2+-activated K + channels, and for N-type Ca 2 ...
Calcicludine is a blocker of high-voltage-activated calcium channels (L-, N- and P-type channels). It has highest affinity to the L-type calcium channel (IC 50 = 88nM[2]). ]). However, sensitivity of the drug on the channel depends on the species and the
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Kaliseptine is a 36 amino acid peptide and contains three disulfide bonds. [1] [4] Kaliseptine shows structural similarities with other sea anemone toxins like Actinia equina K +-channel toxin (), Bunodosoma granulifera K +-channel toxin and Stichodactyla helianthus K +-channel toxin ().
HsTx1 is characterized by a single polypeptide chain of 34 amino acid residues containing 8 Cysteine residues and an amidated C-Terminal end. Its core has a hydrophobic structure and the backbone displays one α-helix and two β-sheets regions that connect the N-terminal and the C-terminal ends.
Cepentil (Tsepentil, N-Cyclopentyllysergamide, LCyP), is an analogue of LSD developed in the former Soviet Union which acts as an antagonist at serotonin receptors.It is not a hallucinogen in animal studies, instead being described as an "energizer" by contemporary sources, suggesting an action similar to the antidementia drug hydergine, however the pharmacology of cepentil has not been ...
This is a list of Latin words with derivatives in English language. Ancient orthography did not distinguish between i and j or between u and v. [1] Many modern works distinguish u from v but not i from j. In this article, both distinctions are shown as they are helpful when tracing the origin of English words. See also Latin phonology and ...
CSTX-1 is the most abundant peptide of the venom of C. salei with concentration ranging from 1.4 to 3.3 mM. It is the most toxic component, and is the principle neurotoxin of the spider.