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The n-octanol-water partition coefficient, K ow is a partition coefficient for the two-phase system consisting of n-octanol and water. [1] K ow is also frequently referred to by the symbol P, especially in the English literature. It is also called n-octanol-water partition ratio. [2] [3] [4]
The partition coefficient between n-Octanol and water is known as the n-octanol-water partition coefficient, or K ow. [62] It is also frequently referred to by the symbol P, especially in the English literature. It is also known as n-octanol-water partition ratio. [63] [64] [65]
Coefficients for partition between water and solvents wet/dry solvent c e s a b v source w 1-butanol: 0.376 0.434 -0.718 -0.097 -2.350 2.682 [1]w
Bioconcentration factors can also be related to the octanol-water partition coefficient, K ow. The octanol-water partition coefficient (K ow) is correlated with the potential for a chemical to bioaccumulate in organisms; the BCF can be predicted from log K ow, via computer programs based on structure activity relationship (SAR) [7] or through ...
A calculated octanol-water partition coefficient (Clog P) that does not exceed 5; Note that all numbers are multiples of five, which is the origin of the rule's name. As with many other rules of thumb, such as Baldwin's rules for ring closure, there are many exceptions.
A model compound for the lipophilic cellular membrane is 1-octanol (a lipophilic medium-chain fatty alcohol), so the logarithm of the octanol-water partition coefficient, known as LogP, is used to predict the solubility of a potential oral drug. This coefficient can be experimentally measured or predicted computationally, in which case it is ...
Octanol-water partition coefficients Critical data The mixture data banks contain (as of April 2007 [update] ) approx. 308,000 data sets with 2,157,000 data points for 10,750 components building 84,870 different binary, ternary, and higher systems/combinations.
For nonionic organic contaminants, the K OC can be determined based on the octanol-water partition coefficient (K OW). C OC is the organic carbon normalized sediment concentration (micrograms per kilogram OC) and C d is the dissolved interstitial water concentration (milligrams per liter). The equation above can be rearranged to: C OC = K OC C d.