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Pitolisant is indicated in adults for the treatment of narcolepsy. [3] [4] Narcolepsy is a chronic sleep disorder that causes overwhelming daytime drowsiness. [4] Pitolisant is also indicated to improve alertness and reduce excessive daytime sleepiness in adults with obstructive sleep apnea. [5] [12]
Narcolepsy can occur in both men and women at any age, although typical symptom onset occurs in adolescence and young adulthood. There is about a ten-year delay in diagnosing narcolepsy in adults. [25] Cognitive, educational, occupational, and psychosocial problems associated with the excessive daytime sleepiness of narcolepsy have been documented.
Pitolisant has been shown to be effective and well-tolerated for the treatment of narcolepsy with or without cataplexy. [182] [181] [180] Pitolisant is the only non-controlled anti-narcoleptic drug in the US. [180] It has shown minimal abuse risk in studies. [180] [183]
Patients with narcolepsy are diagnosed as either type 1 or type 2, with only the former presenting cataplexy symptoms. [58] Type 1 narcolepsy results from the loss of approximately 70,000 orexin-releasing neurons in the lateral hypothalamus, leading to significantly reduced cerebrospinal orexin levels; [59] [60] this reduction is a diagnostic ...
Solriamfetol is used to promote wakefulness in the treatment of excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea in adults. [1] It appears to be more effective in improving excessive daytime sleepiness associated with obstructive sleep apnea than certain other wakefulness-promoting agents including modafinil, armodafinil, and pitolisant.
Experts say cataplexy, which is a loss of muscle tone, often accompanies narcolepsy. In the video, Sarah was working on a traditional Japanese dance to send to a choreographer friend ...
Sodium oxybate, sold under the brand name Xyrem among others, is a medication used to treat symptoms of narcolepsy: sudden muscle weakness and excessive daytime sleepiness. [3] [8] [9] It is used sometimes in France and Italy as an anesthetic given intravenously.
Sorting out prescriptions and device replacement without the documents you’d typically have on hand may take longer. “The last thing we want is for people to end up in the emergency ...