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Tumors of the hematopoietic and lymphoid tissues ( American English) or tumours of the haematopoietic and lymphoid tissues ( British English) are tumors that affect the blood, bone marrow, lymph, and lymphatic system. [1] [2] Because these tissues are all intimately connected through both the circulatory system and the immune system, a disease ...
Lymphoma is the most common form of hematological malignancy, or "blood cancer", in the developed world. Taken together, lymphomas represent 5.3% of all cancers (excluding simple basal cell and squamous cell skin cancers) in the United States and 55.6% of all blood cancers.
Hodgkin lymphoma ( HL) is a type of lymphoma in which cancer originates from a specific type of white blood cell called lymphocytes, where multinucleated Reed–Sternberg cells (RS cells) are present in the patient's lymph nodes. [ 2][ 8] The condition was named after the English physician Thomas Hodgkin, who first described it in 1832. [ 9 ...
In the case of a bone-marrow transplant, the HSCs are removed from a large bone of the donor, typically the pelvis, through a large needle that reaches the center of the bone. The technique is referred to as a bone-marrow harvest and is performed under local or general anesthesia.
Chemotherapy is a drug treatment that involves the use of one or more anti-cancer drugs and is currently the most common treatment method used across all subtypes. [8] T cell lymphoma is typically treated using the CHOP regimen in which four anti-cancer drugs; cyclophosphamide, doxorubicin, vincristine, and prednisone are used in combination at ...
Lymphoid cells include T cells, B cells, natural killer cells, and innate lymphoid cells. The definition of hematopoietic stem cell has developed since they were first discovered in 1961. [5] The hematopoietic tissue contains cells with long-term and short-term regeneration capacities and committed multipotent, oligopotent, and unipotent ...
CHOP is the acronym for a chemotherapy regimen used in the treatment of non-Hodgkin lymphoma. CHOP consists of: C yclophosphamide, an alkylating agent which damages DNA by binding to it and causing the formation of cross-links. H ydroxydaunorubicin (also called doxorubicin or adriamycin), an intercalating agent which damages DNA by inserting ...
Tumor-infiltrating lymphocytes (TIL) are white blood cells that have left the bloodstream and migrated towards a tumor. They include T cells and B cells and are part of the larger category of ‘tumor-infiltrating immune cells’ which consist of both mononuclear and polymorphonuclear immune cells, (i.e., T cells, B cells, natural killer cells ...