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1 in 7,500 males (haemophilia A), 1 in 40,000 males (haemophilia B) [2] [5] Haemophilia ( British English ), or hemophilia ( American English ) [ 6 ] (from Ancient Greek αἷμα ( haîma ) 'blood' and φιλία ( philía ) 'love of'), [ 7 ] is a mostly inherited genetic disorder that impairs the body's ability to make blood clots , a process ...
The prevalence of Hemophilia B in the population is about one in 40,000; Hemophilia B represents about 15% of patients with hemophilia. [6] Many women carriers of the disease have no symptoms. [ 6 ] However, an estimated 10-25% of women carriers have mild symptoms; in rare cases, women may have moderate or severe symptoms.
In the XY sex-determination system, the female-provided ovum contributes an X chromosome and the male-provided sperm contributes either an X chromosome or a Y chromosome, resulting in female (XX) or male (XY) offspring, respectively. Hormone levels in the male parent affect the sex ratio of sperm in humans. [25]
Qatar has the highest male-to-female ratio, with 2.87 males/female. For the group aged below 15, Sierra Leone has the lowest female-to-male ratio with 0.96 males/female, and the Republic of Georgia and the People's Republic of China are tied for the highest male-to-female ratio with 1.13 males/female (according to the 2006 CIA World Factbook).
Haemophilia A (or hemophilia A) is a blood clotting disorder caused by a genetic deficiency in clotting factor VIII, thereby resulting in significant susceptibility to bleeding, both internally and externally. This condition occurs almost exclusively in males born to carrier mothers due to X-linked recessive inheritance.
This leads to sex-based differences at the molecular level for all male and female cells. [5] In males, the X chromosome carries only maternal imprints, while in females X chromosomes are present with both maternal and paternal imprints. In female cells, random processes of X-inactivation "turn off" the extra X chromosome. As a result, females ...
Less than 4 percent of certified doctors practice in rural areas. The real numbers could be even lower. Government databases list doctors who have retired or face licensing issues. They don’t distinguish between those who may decide to prescribe buprenorphine only for chronic pain and those who treat opioid addiction.
Those species with male care and polyandry invariably have adult sex ratios with a large surplus of males, [25] which in some cases can reach as high as six males per female. [ 26 ] Male-biased adult sex ratios have also been shown to correlate with cooperative breeding in mammals such as alpine marmots and wild canids . [ 27 ]