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The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer (see figure), where each zinc is bonded to two sulfur and three oxygen centers. [3] In solution, however, the dimers dissociate via scission of one Zn-O bond ...
Salicylic acid shampoos: Help exfoliate dead skin cells and unclog pores. Ketoconazole or zinc pyrithione shampoos: Effective for fungal-related scalp acne or dandruff.
Like selenium sulfide, zinc pyrithione (a zinc complex with two chelating pyrithione anions) also reduces epidermal turnover and inhibits fungal growth. [3] [unreliable medical source?] It is often administered with ketoconazole for better results. The symptoms do not resolve completely even after prolonged medication.
Shampoo or soap containing zinc pyrithione or selenium disulfide is also used. [8] These options should be used on a daily basis but may also be used in conjunction with a ketoconazole shampoo regimen on alternate days. [8] It is unclear if other antifungals are equally effective as this has not been sufficiently studied. [10]
Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff, seborrhoeic dermatitis and eczema. [2] Climbazole has shown a high in vitro and in vivo efficacy against Malassezia spp. that appear to play an important role in the pathogenesis of dandruff. [2]
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Chattem announced that on November 1, 2005, they would introduce a new line of shampoos under the brand name Selsun Salon. These contained a different active ingredient than Selsun Blue, pyrithione zinc 1%, and are oriented toward the higher-end shampoo market. Other active ingredients such as salicylic acid and botanicals are in other versions ...
Dandruff with shed hair can be symptomatic of dry skin (shed skin scales and hairs on a dark wooden tabletop) The cause is unclear but believed to involve a number of genetic and environmental factors. [7] As the skin layers continually replace themselves, cells are pushed outward where they die and flake off. For most individuals, these flakes ...
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