Search results
Results from the WOW.Com Content Network
Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [2] [3] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution, although only in a few cases are genes the primary cause of obesity.
Fat mass and obesity-associated protein, also known as alpha-ketoglutarate-dependent dioxygenase FTO, is an enzyme that in humans is encoded by the FTO gene located on chromosome 16. As one homolog in the AlkB family proteins, it is the first messenger RNA (mRNA) demethylase that has been identified. [ 5 ]
Chromosome 9 is one of the 23 pairs of chromosomes in humans.Humans normally have two copies of this chromosome, as they normally do with all chromosomes. Chromosome 9 spans about 138 million base pairs of nucleic acids (the building blocks of DNA) and represents between 4.0 and 4.5% of the total DNA in cells.
Pathophysiology of obesity is the study of disordered physiological processes that cause, result from, or are otherwise associated with obesity. A number of possible pathophysiological mechanisms have been identified which may contribute in the development and maintenance of obesity.
Monogenic obesity is excess weight caused by a mutation in a single gene, as opposed to syndromic obesity not tied to a single gene variation and most obesity, which is caused by multiple genetic and environmental risk factors. Monogenetic obesity mostly affects the hypothalamus and leptin–melanocortin system (see hypothalamic obesity ...
Obesity is one of the leading preventable causes of death worldwide. [38] [39] [40] The mortality risk is lowest at a BMI of 20–25 kg/m 2 [41] [37] [42] in non-smokers and at 24–27 kg/m 2 in current smokers, with risk increasing along with changes in either direction. [43] [44] This appears to apply in at least four continents. [42]
Chromosome 16 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. People normally have two copies of this chromosome. Chromosome 16 spans about 90 million base pairs (the building material of DNA) and represents just under 3% of the total DNA in cells .
This is because males' cells have only one copy of the Y-chromosome. X-chromosomes have two copies, one from each parent permitting recombination. The X chromosome contains more genes and is substantially larger. Some ostensibly Y-linked traits have not been confirmed. One example is hearing impairment.