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[114] [104] [110] [111] Lipitor was on the market by 1996. [112] [115] By 2003, Lipitor had become the best selling pharmaceutical in the United States. [108] From 1996 to 2012, under the trade name Lipitor, atorvastatin became the world's best-selling medication of all time, with more than $125 billion in sales over approximately 14.5 years.
[5] [65] Over 5 years of treatment statins result in 75 cases of diabetes, 7.5 cases of bleeding stroke, and 5 cases of muscle damage per 10,000 people treated. [34] This could be due to the statins inhibiting the enzyme (HMG-CoA reductase), which is necessary to make cholesterol, but also for other processes, such as CoQ 10 production, which ...
Statins are linked to better health outcomes in older adults over the age of 70 with or without previous cardiovascular disease, a new study finds.
A new way of determining heart disease risk may result in millions fewer people getting prescriptions for statins, according to new research. Heart doctors warned, however, that more information ...
Consuming more than 45% of daily calories after 5 p.m. can contribute to greater risk of type 2 diabetes, cardiovascular problems, and chronic inflammation, a recent study suggests.
Torcetrapib (CP-529,414, Pfizer) was a drug being developed to treat hypercholesterolemia (elevated cholesterol levels) and prevent cardiovascular disease.Its development was halted in 2006 when phase III studies showed excessive all-cause mortality in the treatment group receiving a combination of atorvastatin (Lipitor) and torcetrapib.
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Sundowning also tends to happen consistently around the same time of day, Elhelou says. “It often includes cognitive effects such as significant disorientation or impaired judgement,” she says.