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Mifepristone is used in more than half of all abortions in the US. The drug was first approved for use by the US Food and Drug Administration in most cases up to 10 weeks of pregnancy in 2000.
Vaginal bleeding generally diminishes gradually over about two weeks after a medical abortion, but in individual cases spotting can last up to 45 days. [44] Emergency surgical or medical interventions for prolonged bleeding may be considered based on how the patient feels and if the bleeding seems to be getting better.
Mifepristone is currently in the middle of a political tug-of-war, with some conservative states seeking to restrict or eliminate access to the abortion pill, while other states are trying to ...
Mifepristone is a steroidal antiprogestogen (IC 50 = 0.025 nM for the PR), as well as an antiglucocorticoid (IC 50 = 2.2 nM for the GR) and antiandrogen (IC 50 = 10 nM for the AR) to a much lesser extent. [48] It antagonizes cortisol action competitively at the receptor level. [49]
Plan C conducts research and publicly shares information about how people are accessing mifepristone and misoprostol abortion pills in the US. Their stated goal is to transform access to abortion in the United States by normalizing the self-directed option of abortion pills by mail and placing the ability to end an early pregnancy directly in the hands of anyone who seeks it.
Mifepristone is one of two drugs used in medication abortion in the U.S. But mifepristone has many uses in reproductive care and in other contexts, experts say.
In 2000, GenBioPro's generic version of mifepristone was approved for medication abortion, as part of a two-drug regimen in combination with misoprostol. In 2023, GenBioPro sued the FDA to obtain a legal judgement confirming that mifepristone could continue to be sold, in spite of anti-abortion laws passed in some states.
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