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Mifepristone is used in more than half of all abortions in the US. The drug was first approved for use by the US Food and Drug Administration in most cases up to 10 weeks of pregnancy in 2000.
Mifepristone is a steroidal antiprogestogen (IC 50 = 0.025 nM for the PR), as well as an antiglucocorticoid (IC 50 = 2.2 nM for the GR) and antiandrogen (IC 50 = 10 nM for the AR) to a much lesser extent. [48] It antagonizes cortisol action competitively at the receptor level. [49]
This isn't the first time that abortion pill access has been called into question: Project 2025, a framework laid out by Trump allies, targets getting abortion pills by mail.
Pro-choice advocates say the science is settled on the abortion pill mifepristone, but critics argue that better safeguards need to be in place after the FDA relaxed them in recent years.
Mifepristone is one of two drugs used in medication abortion in the U.S. But mifepristone has many uses in reproductive care and in other contexts, experts say.
The half-life is decreased by 30-50% in adult male smokers, approximately doubled in women taking oral contraceptives, and prolonged in the last trimester of pregnancy. [127] In newborns the half-life can be 80 hours or more, dropping rapidly with age, possibly to less than the adult value by age 6 months. [ 127 ]
Mifepristone is currently in the middle of a political tug-of-war, with some conservative states seeking to restrict or eliminate access to the abortion pill, while other states are trying to ...
Modafinil performs moderately (but better than armodafinil or solriamfetol) [30] as a drug to overcome excessive daytime sleepiness caused by obstructive sleep apnea, [31] though it is recommended that people with apnea use continuous positive airway pressure (CPAP) therapy, that is a sleep breathing apparatus to prevent apnea, before starting ...
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