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Sitagliptin, sold under the brand name Januvia among others, is an anti-diabetic medication used to treat type 2 diabetes. [8] In the United Kingdom it is listed as less preferred than metformin or a sulfonylurea . [ 9 ]
In the United States, sitagliptin/metformin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. [5] [6]In the European Union, sitagliptin/metformin is indicated as an adjunct to diet and exercise to improve glycemic control in people with type 2 diabetes; in combination with a sulfonylurea as an adjunct to diet and exercise "in people ...
Combining resistance exercise with a calorie deficit helps preserve muscle mass and improves muscle strength during weight loss, according to a 2017 review in Advances in Nutrition.
The pharmacokinetic properties of sitagliptin and vildagliptin appear unaffected by age, sex or BMI. [18] Clinical researches have shown that sitagliptin and vildagliptin do not have the side effects that tend to follow type 2 diabetes treatment, e.g. weight gain and hyperglycemia , but however, other side effects have been observed, including ...
Powerful weight-loss drugs are expanding use of U.S. health care as patients starting prescriptions are diagnosed with obesity-related conditions or take the drugs to become eligible for other ...
Merck’s Januvia is around $6,000 in the U.S. but $900 in Canada and $200 in France. The CEOs defended the costs, saying those high prices are based on the “value” the medications give patients.
A 2020 Cochrane systematic review did not find enough evidence of reduction of all-cause mortality, serious adverse events, cardiovascular mortality, non-fatal myocardial infarction, non-fatal stroke or end-stage renal disease when comparing metformin monotherapy to dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes. [25]
For Risperdal the risks were substantial. Even in the earliest trials, the data showed significant rates of side effects. These included involuntary twitches, somnolence, diabetes and, most frequently, significant weight gain. In the elderly there was a particularly high risk of strokes and other heart-related diseases.