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Gout affects about 1–2% of adults in the developed world at some point in their lives. [7] It has become more common in recent decades. [3] This is believed to be due to increasing risk factors in the population, such as metabolic syndrome, longer life expectancy, and changes in diet. [7] Older males are most commonly affected. [3]
Because of this, diet and lifestyle changes alone may not be enough to address the source of the condition, the abundance of uric acid in the body. 9 Gout becomes out of control when a person ...
Colchicine is an alternative for those unable to tolerate NSAIDs when treating gout. [20][21][22][23] Low doses (1.2 mg in one hour, followed by 0.6 mg an hour later) appear to be well tolerated and may reduce gout symptoms and pain, perhaps as effectively as NSAIDs. [24] At higher doses, side effects (primarily diarrhea, nausea, or vomiting ...
Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C 5 H 4 N 4 O 3. It forms ions and salts known as urates and acid urates, such as ammonium acid urate. Uric acid is a product of the metabolic breakdown of purine nucleotides, and it is a normal component of urine. [1]
Gout is a form of inflammatory arthritis characterized by recurrent attacks of a single red, ... levels of uric acid can be lowered via lifestyle changes or allopurinol.
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Unless high blood levels of uric acid are determined in a clinical laboratory, hyperuricemia may not cause noticeable symptoms in most people. [5] Development of gout – which is a painful, short-term disorder – is the most common consequence of hyperuricemia, which causes deposition of uric acid crystals usually in joints of the extremities, but may also induce formation of kidney stones ...
Pegloticase is a PEGylated recombinant porcine -like uricase. Similarly to rasburicase, it metabolises uric acid to allantoin. This reduces the risk of urate precipitates, since allantoin is five to ten times more soluble than uric acid. In contrast to rasburicase, pegloticase is PEGylated to increase its elimination half-life from about eight ...
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