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Methylprednisolone (Depo-Medrol, Medrol, Solu-Medrol) is a synthetic glucocorticoid, primarily prescribed for its anti-inflammatory and immunosuppressive effects. [4] [5] [6] It is either used at low doses for chronic illnesses or used concomitantly at high doses during acute flares.
IV infusion: Day 0 Etoposide: 40 mg/m 2: IV infusion over 1 hr: Days 1-4 Solu-Medrol - Methylprednisolone: 500 mg: IV bolus over 15 min: Days 1-5 High-dose Ara-C — cytarabine: 2000 mg/m 2: IV infusion over 2 hrs: Day 5 Platinol (cisplatin) 25 mg/m 2: IV continuous infusion over 24 hrs: Days 1-4
Chemical structure of methylprednisolone. Corticosteroids are used during acute multiple sclerosis relapses. Administration of high doses of intravenous corticosteroids, such as methylprednisolone, is the routine therapy for acute relapses.
[1] [4] [5] Methylprednisolone acetate was previously suspended with polyethylene glycol but is no longer formulated with this excipient due to concerns about possible toxicity. [6] [8] Depo methylprednisolone acetate is a depot injection and is absorbed slowly with a duration of weeks to months with a single intramuscular injection. [5]
Methylprednisolone succinate, sold under the brand name Solu-Medrol among others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester—specifically the C21 succinate ester of methylprednisolone—which is used by intravenous administration.
Subcutaneous administration is the insertion of medications beneath the skin either by injection or infusion. A subcutaneous injection is administered as a bolus into the subcutis , the layer of skin directly below the dermis and epidermis , collectively referred to as the cutis .
Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein.The intravenous route of administration is commonly used for rehydration or to provide nutrients for those who cannot, or will not—due to reduced mental states or otherwise—consume food or water by mouth.
Typical starting choices are hydrocortisone 100 mg IV q8h, prednisolone 30 mg IV q12h, or methylprednisolone 16–20 mg IV q8h. The last two are preferred due to less sodium retention and potassium wasting. 24-hour continuous infusion is preferred than the stated dosing.
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