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  2. Adrenergic receptor - Wikipedia

    en.wikipedia.org/wiki/Adrenergic_receptor

    Epinephrine (adrenaline) reacts with both α- and β-adrenoreceptors, causing vasoconstriction and vasodilation, respectively. Although α receptors are less sensitive to epinephrine, when activated at pharmacologic doses, they override the vasodilation mediated by β-adrenoreceptors because there are more peripheral α 1 receptors than β ...

  3. Beta-2 adrenergic receptor - Wikipedia

    en.wikipedia.org/wiki/Beta-2_adrenergic_receptor

    The beta-2 adrenergic receptor (β 2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that binds epinephrine (adrenaline), a hormone and neurotransmitter whose signaling, via adenylate cyclase stimulation through trimeric G s proteins, increases cAMP, and, via downstream L-type calcium channel interaction, mediates physiologic responses such as smooth ...

  4. Beta2-adrenergic agonist - Wikipedia

    en.wikipedia.org/wiki/Beta2-adrenergic_agonist

    Like other β adrenergic agonists, they cause smooth muscle relaxation. β 2 adrenergic agonists' effects on smooth muscle cause dilation of bronchial passages, vasodilation in muscle and liver, relaxation of uterine muscle, and release of insulin. They are primarily used to treat asthma and other pulmonary disorders.

  5. Beta-1 adrenergic receptor - Wikipedia

    en.wikipedia.org/wiki/Beta-1_adrenergic_receptor

    153 11554 Ensembl ENSG00000043591 ENSMUSG00000035283 UniProt P08588 P34971 RefSeq (mRNA) NM_000684 NM_007419 RefSeq (protein) NP_000675 NP_031445 Location (UCSC) Chr 10: 114.04 – 114.05 Mb Chr 19: 56.71 – 56.72 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The beta-1 adrenergic receptor (β 1 adrenoceptor), also known as ADRB1, can refer to either the protein-encoding gene ...

  6. Adrenergic antagonist - Wikipedia

    en.wikipedia.org/wiki/Adrenergic_antagonist

    Adrenergic antagonists reverse the natural cardiovascular effect, based on the type of adrenoreceptor being blocked. For example, if the natural activation of the α 1-adrenergic receptor leads to vasoconstriction, an α 1-adrenergic antagonist will result in vasodilation. [3]

  7. Adrenergic neuron blockers - Wikipedia

    en.wikipedia.org/wiki/Adrenergic_neuron_blockers

    Alpha 1 receptor blockade, which results in vascular smooth muscle relaxation and consequent vasodilation, is the cause of hypotension. [7] The occurrence of greater release of norepinephrine when numerous alpha 2 receptors are antagonised is what causes the remaining side effects. [7]

  8. Vascular smooth muscle - Wikipedia

    en.wikipedia.org/wiki/Vascular_smooth_muscle

    Agonists of alpha-2 receptors in the vascular smooth muscle lead to vasoconstriction. However, in clinical practice drugs applied intravenously that are agonists of alpha-2 receptors such as clonidine lead to powerful vasodilation, which causes a decrease in blood pressure by presynaptic activation of the receptors in the sympathetic ganglia ...

  9. Alpha-1 adrenergic receptor - Wikipedia

    en.wikipedia.org/wiki/Alpha-1_adrenergic_receptor

    alpha-1 (α 1) adrenergic receptors are G protein-coupled receptors (GPCRs) associated with the G q heterotrimeric G protein. α 1-adrenergic receptors are subdivided into three highly homologous subtypes, i.e., α 1A-, α 1B-, and α 1D-adrenergic receptor subtypes.

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