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The organic compound citrulline is an α-amino acid. [2] Its name is derived from citrullus, the Latin word for watermelon.Although named and described by gastroenterologists since the late 19th century, it was first isolated from watermelon in 1914 by Japanese researchers Yatarō Koga (古賀彌太郎) and Ryō Ōtake (大嶽了) [3] [4] and further codified by Mitsunori Wada of Tokyo ...
One source recommends an L-citrulline dosage of 2,000 milligrams three times a day, or 1.76 grams of citrulline malate for every 1 gram of citrulline you might take for circulatory health.
Malic acid has two stereoisomeric forms (L- and D-enantiomers), though only the L-isomer exists naturally. The salts and esters of malic acid are known as malates . The malate anion is a metabolic intermediate in the citric acid cycle .
3 L-citrulline 4 argininosuccinate 5 fumarate 6 L-arginine 7 urea ... This malate is then oxidized to oxaloacetate by cytosolic malate dehydrogenase, ...
Citrulline is not one of the 20 standard amino acids encoded by DNA in the genetic code. Instead, it is the result of a post-translational modification. Citrullination is distinct from the formation of the free amino acid citrulline as part of the urea cycle or as a byproduct of enzymes of the nitric oxide synthase family.
Watermelon and 100% watermelon juice are notable for a compound called l-citrulline, which has been shown to reduce muscle soreness after exercising. Watermelon is also a good choice after a ...
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