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Prepubertal hypertrichosis, also known as childhood hypertrichosis, is a cutaneous condition characterized by increased hair growth, found in otherwise healthy infants and children. [ 1 ] [ 2 ] Prepubertal hypertrichosis is a cosmetic condition and does not affect any other health aspect.
Hyperpituitarism is a condition due to the primary hypersecretion of pituitary hormones; [3] [medical citation needed] it typically results from a pituitary adenoma.In children with hyperpituitarism, disruption of growth regulation is rare, either because of hormone hypersecretion or because of manifestations caused by local compression of the adenoma.
These people typically exhibit growth failure in their early to mid-childhood years. [4] Similar to type II isolated growth hormone deficiency, type III is characterized by extremely low growth hormone levels and variable degrees of short height in the affected individuals. Type III growth failure typically manifests in early to mid-childhood.
GH is one of the treatment options an experienced endocrinologist may use when treating a child with PWS. [17] GH can help children with PWS in height, weight, body mass, strength, and agility. [citation needed]. Reports have indicated increase of growth rate (especially in the first year of treatment) and a variety of other positive effects ...
Diagnosis involves blood tests to measure growth hormone levels. [2] Treatment is by growth hormone replacement using synthetic human growth hormone. [1] The frequency of the condition is unclear. [2] Most cases are initially noticed in children. [1] The genetic forms of this disease are estimated to affect about 1 in 7,000 people. [3]
As of December 2020, the treatment of achondroplasia with human growth hormone was approved only in Japan. [35] A small-molecule drug vosoritide is used to improve growth velocity in children with achondroplasia, [10] although its long-term effects are unknown. Vosoritide inhibits the activity of FGFR3. [36]
The disorder may be accompanied by autism, [1] mild intellectual disability, delayed motor, cognitive, and social development, hypotonia (low muscle tone), and speech impairments. Children with Sotos syndrome tend to be large at birth and are often taller, heavier, and have relatively large skulls (macrocephaly) than is
Latitudinal and longitudinal growth may be affected. [1] [2] [3] Nevertheless, the musculoskeletal features are central to the diagnosis of some syndromes such as Proteus syndrome. [2] The time of presentation of children with overgrowth syndromes is an important contributor to the differential diagnosis.