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It involves a patent ostium secundum (that is, a patent foramen secundum). The secundum atrial septal defect usually arises from an enlarged foramen ovale, inadequate growth of the septum secundum, or excessive absorption of the septum primum. About 10 to 20% of individuals with ostium secundum ASDs also have mitral valve prolapse. [5]
Foramen secundum atrial septal defects are the most common atrial septal defects. This defect can arise as a result of defects of the septum primum and the septum secundum. For the septum primum, the problem can arise as a result of excess resorption of the septum during the process of apoptosis in order to form the foramen secundum.
Initially the atria are separated from one another by the septum primum except for a small opening below the septum, the ostium primum. As the septum primum grows, the ostium primum narrows and eventually closes. Before it does so, bloodflow from the inferior vena cava wears down a portion of the septum primum, forming the ostium secundum.
Septal defects that may occur with Lutembacher's syndrome include: Ostium primum atrial septal defect or ostium secundum which is more prevalent. [1] Lutembacher's syndrome affects females more often than males. [1] It can affect children or adults; the person can either be born with the disorder or develop it later in life.
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The ostium primum atrial septal defect is a defect in the atrial septum at the level of the tricuspid and mitral valves. This is sometimes known as an endocardial cushion defect because it often involves the endocardial cushion, which is the portion of the heart where the atrial septum meets the ventricular septum and the mitral valve meets the tricuspid valve.
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