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Terbinafine is an antifungal medication used to treat pityriasis versicolor, fungal nail infections, and ringworm including jock itch and athlete's foot. [1] [2] [3] It is either taken by mouth or applied to the skin as a cream or ointment. [1] [4] The cream and ointment should not be used for fungal nail infections. [5]
Topical antifungal medications usually come with side effects. Some patients may develop itching or local irritations after the application of these products. Consult a pharmacist or clinician if the treated area shows signs of increased irritation or possible sensitization such as erythema , pruritus , burning, blistering , swelling , or oozing.
Tolnaftate [1] sold under the brand name TAGRID among, others is a synthetic thiocarbamate used as an anti-fungal agent that may be sold without medical prescription in most jurisdictions. It is supplied as a cream, powder, spray, liquid, and liquid aerosol . [ 2 ]
[1] Common side effects include allergic reactions, nausea, diarrhea, headache, trouble sleeping, and feeling tired. [1] It is not recommended in people with liver failure or porphyria. [1] Use during or in the months before pregnancy may result in harm to the baby. [1] [2] Griseofulvin works by interfering with fungal mitosis. [1]
The side effects of oral treatment are significant and people without an infection should not take these drugs. [36] Azoles are the group of antifungals which act on the cell membrane of fungi. They inhibit the enzyme 14-alpha-sterol demethylase, a microsomal CYP, which is required for the biosynthesis of ergosterol for the cytoplasmic membrane.
Like the allylamine antifungals (e.g terbinafine), butenafine works by inhibiting the synthesis of ergosterol by binding to and inhibiting squalene epoxidase, an enzyme in the pathway used for creation of the sterols needed in fungal cell membranes. Lacking ergosterol, the cell membranes increase in permeability, allowing their contents to leak ...
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